Synthesis, characterization and antimicrobial screening of novel quinoline-thiazole derivatives
نویسندگان
چکیده
2-Chloroquinoline-3-carbaldehyde 1 reacts with 2-cyanoacetohydrazide in ethanol to result in 1-[1-aza-2-(2-chloro(3quinolyl))vinyl]-2-cyanoacetamide 2. Phenyl isothiocyanate added to a stirred solution of compound 2, sulphur and triethylamine in a mixed solvent of dimethylformamide : ethanol to result in N-[1-aza-2-(2-chloro(3-quinolyl))vinyl](4amino-3-phenyl-2-thioxo(1,3-thiazoline-5-yl)) carboxamide 3. Compound 3 reacts with different aldehydes in ethanol to yield {4-[1-aza-2-(aryl)vinyl]-3-phenyl-2-thioxo(1,3-thiazolin-5-yl)}-N-[1-aza-2-(2-chloro(3-quinolyl))vinyl]carboxamides 4a-l. These newly synthesized compounds 4a-l have been screened for their antibacterial activity on Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogenes, and antifungal activity on Candida albicans, Aspergillus niger and Aspergillus clavatus.
منابع مشابه
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